Whole Genome Bisulfite Sequencing

Whole Genome Bisulfite Sequencing (WGBS) is the gold-standard next-generation sequencing method used to map and quantify DNA methylation at single-base resolution across an entire genome.

Key Applications:

• Cancer Research: Identifies epigenetic biomarkers, maps tumor heterogeneity, and analyzes aberrant DNA methylation patterns driving tumor development.

• Developmental Biology: Tracks dynamic epigenetic reprogramming, embryonic development, and cell differentiation patterns.

• Gene Regulation Studies: Maps regulatory elements like promoters, enhancers, and intergenic regions to understand transcriptional silencing and imprinting.

• Complex Disease Research: Investigates epigenetic contributions to autoimmune, cardiovascular, and mental health disorders.

• Plant and Animal Breeding: Analyzes methylome variations to enhance agricultural traits in crops and livestock.